|
KMID : 0356820170330010001
|
|
Korean Journal of Head & Neck Oncology
2017 Volume.33 No. 1 p.1 ~ p.5
|
|
|
Immune Evasion Mechanism as a Guide for Immunotherapy in Head and Neck Cancer
|
|
Chang Hyun
|
|
|
Abstract
|
|
|
|
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer globally with high morbidity and mortality. Immune surveillance is well recognized as an important mechanism to prevent development or progression of HNSCC. HNSCC can escape the immune system through multiple mechanisms including development of tolerance in T cells and inhibition of T-cell-related pathways, generally referred to as checkpoint inhibitors. Recent clinical trials have demonstrated a clear advantage in advanced HNSCC patients treated with immune checkpoint blockade. Right at the front of the new era of immunotherapy, we will review current knowledge of immune escape mechanisms and clinical implication for HNSCC.
|
|
|
KEYWORD
|
|
|
Head and neck cancer , Immune surveillance , Immune escape , Immuno-oncology drug
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|